Misconceptions Regarding Peptide Synthesis

Since the mid 1960s, there have been a lot of developments in the field of peptide synthesis, and a lot of methods have come into existence, with solid phase peptide synthesis being one of them. There is a lot still happening to refine the processes, discover new synthesis methods and improve the overall quality of products. In most cases, those in need of synthetic peptides can obtain them on readymade peptide synthesis schemes and these include liquid phase synthesis, solid phase synthesis and also large scale production.


Most of the time, the commonly used method to produce peptides is to simply purchase amino acids from some of the leading chemical producers in the world than use the amino acids as a raw material for the production of synthetic peptides. During the fifties and the sixties in the past century, most peptides were obtained strictly from animal organs. If you consider thymosin, for example, it used to be extracted from the thymus of a newborn calf and then the thymus peptide was separated using shock separation technology. Peptides were frequently used for human immunity back in the days.

Currently, such peptides are not in use anymore due to the mad cow disease. The virus responsible for causing this disease has the ability to engulf the animal protein in the brain and this can lead to the destruction of brain tissues, nerves and brain cells. When the virus accesses the human body through injection, it becomes even more lethal than cancer and patients who are unlucky enough to get it will soon get into a vegetative state or simply die.

For those who are just starting out in the world of peptides and peptide synthesis, it will be important to understand the principle of particular peptide synthesis as well as other specific processes surrounding the concept. You will have to familiarize yourself with terms such as deprotection, resin swelling, and coupling, which consist of the basic terminology and processes in the field of peptide synthesis.